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ISSN 0253-2964(Print) ISSN 1229-5949(Online)
Volume 33, Number 5
BKCSDE 33(5)
May 20, 2012 |
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Title |
Metabolic Pharmacokinetics in Rats: Differences between Pure Amygdalin and Amygdalin in a Decoction of Peach Seeds |
Author |
Jianbo Chen, Xitao Yan, Tae Jin Kim, Sang Hyuck Kim, Kyung Tae Kim, Young Keun Lee, Cheong Weon Cho, Jongsuep Baek, Yong Ki Park, Young Ho Kim, Wonjae Lee,* Jong Seong Kang* |
Keywords |
Amygdalin, Prunasin, Peach seed, High performance liquid chromatography, Pharmacokinetic studies |
Abstract |
The pharmacokinetics of prunasin after oral administration of amygdalin or a decoction of peach seeds was determined and compared in rats. A C18 column was used for separation at a column temperature of 25 oC. The mobile phase consisted of 20% aqueous acetonitrile, and the flow rate was 0.5 mL/min. After oral administration of a decoction of peach seeds, prunasin was absorbed rapidly, reaching a maximum plasma concentration (Cmax) of 62.1 mg/L within 45 min. After oral administration of amygdalin, the absorption of prunasin was delayed. The Cmax of prunasin was 42.9 mg/L and was reached at 60 min. Values for the pharmacokinetic parameters of prunasin, including Tmax, Cmax, AUC, T1/2, CL/F, and V1/F, were significantly different for the oral administration of amygdalin compared with that of a decoction of peach seeds. |
Page |
1470 - 1474 |
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