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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 5
BKCSDE 33(5)
May 20, 2012 

Metabolic Pharmacokinetics in Rats: Differences between Pure Amygdalin and Amygdalin in a Decoction of Peach Seeds
Jianbo Chen, Xitao Yan, Tae Jin Kim, Sang Hyuck Kim, Kyung Tae Kim, Young Keun Lee, Cheong Weon Cho, Jongsuep Baek, Yong Ki Park, Young Ho Kim, Wonjae Lee,* Jong Seong Kang*
Amygdalin, Prunasin, Peach seed, High performance liquid chromatography, Pharmacokinetic studies
The pharmacokinetics of prunasin after oral administration of amygdalin or a decoction of peach seeds was determined and compared in rats. A C18 column was used for separation at a column temperature of 25 oC. The mobile phase consisted of 20% aqueous acetonitrile, and the flow rate was 0.5 mL/min. After oral administration of a decoction of peach seeds, prunasin was absorbed rapidly, reaching a maximum plasma concentration (Cmax) of 62.1 mg/L within 45 min. After oral administration of amygdalin, the absorption of prunasin was delayed. The Cmax of prunasin was 42.9 mg/L and was reached at 60 min. Values for the pharmacokinetic parameters of prunasin, including Tmax, Cmax, AUC, T1/2, CL/F, and V1/F, were significantly different for the oral administration of amygdalin compared with that of a decoction of peach seeds.
1470 - 1474
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