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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 1
BKCSDE 33(1)
January 20, 2012

Title	Chemiluminescence Determination of Balofloxacin Based on Europium (III)-Sensitized KBrO₃-Na₂S₂O₄ Reaction in Micellar Medium
Author	Fang Zhao, * Yu Qi, Wei Xiong
Keywords	Chemiluminescence, KBrO₃-Na₂S₂O₄ reaction, Balofloxacin, Europium (III), Sodium dodecyl benzene sulfonate
Abstract	A novel chemiluminescence (CL) flow injection method for the determination of balofloxacin is described. The method is based on the weak CL signal arising from the reaction of KBrO3 with Na2S2O4 in acidic medium being significantly enhanced by balofloxacin in the presence of europium (III) ion and sodium dodecyl benzene sulfonate (SDBS). The experimental conditions that affected CL intensity were carefully optimized and the CL reaction mechanism was briefly discussed. Under the optimum conditions, the relative CL intensity was proportional to the concentration of balofloxacin in the range of 7.0 × 10−11 to 3.0 × 10−7 g mL−1. The detection limit was 2.7 × 10−11 g mL−1 and the relative standard deviation was 2.1% for 7.0 × 10−10 g mL−1 balofloxacin (n = 13). The proposed method was successfully applied to the determination of balofloxacin in pharmaceutical formulations and biological fluids.
Page	204 - 208
Full Text	PDF / Supporting Information

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