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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 1
BKCSDE 33(1)
January 20, 2012

Title	Interaction of Apidaecin Ib with Phospholipid Bilayers and its Edwardsiella Species-specific Antimicrobial Activity
Author	Jung-Kil Seo, Hye-Jin Go, Ho Sung Moon, Min Jeong Lee, Yong-Ki Hong, Hyun Do Jeong, Bo-Hye Nam, Tae Hyun Park, Nam Gyu Park*
Keywords	Apidaecin Ib, Edwardsiella species, Alternatives, Fish pathogenic bacteria
Abstract	Apidaecin Ib had strong antimicrobial activity against several tested Gram-negative bacteria including Escherichia coli, Enterobacter cloacae, and Shigella flexneri (MECs; 0.3-1.5 μg/mL), but showed no activity against all the tested Gram-positive bacteria including Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus and one yeast, Candida albicans (MECs; >125 μg/mL). Interestingly, this peptide showed potent antibacterial activity only against Edwardsiella species (MECs; 0.6-3.6 μg/mL) among the tested fish pathogenic bacteria through a bacteriostatic process and showed no significant hemolytic activity. Apidaecin Ib took an unordered structure in all environments and also had very weak membrane perturbation activity even at 25 μM. Anti-Edwardsiella activity of apidaecin Ib is stronger than those of other antimicrobial polypeptides or antibiotics, but its activity is salt-sensitive. These results suggest that apidaecin Ib has Edwardsiella speciesspecific antibacterial activity and could be applied as new preventive or control additives for Edwardsiella species infection in freshwater fish aquaculture.
Page	115 - 122
Full Text	PDF

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