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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 11
BKCSDE 32(11)
November 20, 2011 

Characterization of Antibacterial Activity and Synergistic Effect of Cationic Antibacterial Peptide-resin Conjugates
Jeong Min Kim, Sujung Jang, Mi-Hwa Yang, Hyeongjin Cho, Keun-Hyeung Lee*
Cationic antibacterial peptide, Antibacterial polymer, Surface modification, Synergistic effect, Antibacterial resin
We synthesized peptide-resin conjugates (1 and 2) by immobilizing β-sheet antibacterial peptide and α helical antibacterial peptide on PEG-PS resin, respectively. Conjugate 1 showed considerable antibacterial activity in various conditions, whereas conjugate 2 did not exhibit antibacterial activity. The growths of various bacteria were inhibited by conjugate 1 even at lower concentrations than MIC. Conjugate 1 killed bacteria at MIC and had a potent synergistic effect with current antibacterial agents such as vancomycin and tetracycline, respectively. Overall results indicate that polymer surface modification using antibacterial β sheet peptide is a powerful way to prevent microbial contamination on polymer surfaces.
3928 - 3932
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