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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 9
BKCSDE 32(9)
September 20, 2011 

Functional and Structural Characterization of Drosocin and its Derivatives Linked O-GalNAc at Thr11 Residue
Mija Ahn, Hoik Sohn, Yong Hai Nan, Ravichandran N. Murugan, Chaejoon Cheong, Eun Kyoung Ryu, Eun-Hee Kim, Shin Won Kang, Eun Joo Kim, Song Yub Shin,*, Jeong Kyu Bang*
Glyco-peptide, Antimicrobial peptide, Drosocin, Structure-Activity Relationship (SAR), Circular Dichroism (CD)
Antimicrobial peptides have recently gained the much attention because of their ability to make defense system from attacking bacterial infections. Drosocin has been considered as very attractive antibiotic agents because of low toxicity against human erythrocytes and active at the low concentration. We have studied the structureactivity relationship of a glycopeptide drosocin focused on the N-acetyl-D-galactoside at Thr11 residue. Based on the radial diffusion assay, we found that the acetylation of carbohydrate moiety increased the antimicrobial activity and the Pro10, present in the middle of drosocin plays an important role in the antimicrobial activity. Our results provide a good lead compound for further studies on the design of drosocin-based analogues targeting glyco linked Thr site.
3327 - 3332
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