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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 8
BKCSDE 32(8)
August 20, 2011 

 
Title
Triazinylmethylphenyl Glucoside as Novel C-Aryl Glucoside SGLT2 Inhibitors
Author
Suk Youn Kang, Min Ju Kim, Jinhwa Lee *
Keywords
SGLT, Dapagliflozin, Triazine, Glucoside, Diabetes
Abstract
Novel C-aryl glucoside SGLT2 inhibitors containing triazine motif were designed and synthesized for biological evaluation. Among the compounds assayed, triazine containing methoxy moiety 18 demonstrated the best in vitro inhibitory activity against hSGLT2 in this series to date (IC50 = 24.9 nM).
Page
2938 - 2940
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