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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 8
BKCSDE 32(8)
August 20, 2011 

Synthesis of triazoloquinoxalines as Antitubercular Agents
Kondapalli Venkata Gowri Chandra Sekhar,*, Vajja Sambasiva Rao, Dalip Kumar
Triazolo quinoxalines, Antitubercular, Iodobenzene diacetate
1,2,4-Triazoles and quinoxalines were found to display various pharmacological activities. Hence a series of 1- aryl-4-methyl-1,2,4-triazolo[4,3-a]quinoxalines were synthesized. Due to various advantages of organic reactions under solvent-free conditions these compounds were developed using iodobenzene diacetate under solvent-free conditions. The synthesized compounds were characterized by elemental microanalysis, infrared spectroscopy, 1H NMR, 13C NMR and HRMS. All the synthesized compounds were investigated for their antitubercular activity and 5g was found to the most active compound.
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