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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 4
BKCSDE 32(4)
April 20, 2011

Title	Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A3 and B Viruses
Author	Jian ping Yong, Haji Akber Aisa*
Keywords	Synthesis, Rupestonic acid ester derivatives, Anti-influenza virus
Abstract	To improve the biological activities of rupestonic acid, 21 new rupestonic acid fatty ester derivatives (2a-2h) and aromatic ester derivatives (2i-2u) were synthesized and preliminarily evaluated for their anti-influenza activity in vitro by the national center for drug screening of China, using the Oseltamivir and Ribavirin as reference drugs. The results showed that 2l (IC₅₀ = 0.5 μmol/L) exhibited potent anti-influenza A₃ viral activity among the synthesized compounds and was 10-fold more potent than that of the reference drug Oseltamivir (IC₅₀ = 5.1 μmol/L).
Page	1293 - 1297
Full Text	PDF

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