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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 3
BKCSDE 32(3)
March 20, 2011 

 
Title
Gd-complexes of DTPA-bis(amide) Conjugates of Phosphonated Tranexamic Esters as MRI Contrast Agents
Author
Mehul A. Patel, Hee Kyung Kim, Gang Ho Lee, Yongmin Chang,*, Tae Jeong Kim*
Keywords
DTPA-bis(amide), MRI CAs, Phosphonates, Tranexamate, Gd-complexes
Abstract
The syntheses of DTPA-bis(amide) conjugates of phosphonated cyclohexane moieties (5a-d) and their Gd(III) complexes of the type [Gd(L)(H2O)]·nH2O (6a-d; L = 5a-d) are described. All new compounds have been characterized by microanalysis and spectroscopic techniques. High r1 relaxivities of aqueous solutions of 6a-d are observed to be in the range of 10.7-18.3 mM−1sec−1, which compare much better than that of Omniscan® (r1 = 3.90 mM−1sec−1).
Page
1022 - 1026
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