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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 2
BKCSDE 32(2)
February 20, 2011

Title	Silica Gel-Supported Polyphosphoric Acid (PPA-SiO₂) Catalyzed One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones: An Efficient Method for the Biginelli Reaction
Author	Mohsen Zeinali Dastmalbaf, Abolghasem Davoodnia*, Majid M. Heravi, Niloofar Tavakoli Hoseini, Amir Khojastehnezhad, Hassan Ali Zamani
Keywords	Biginelli reaction, Heterogeneous catalysis, PPA-SiO₂, Multi-component reactions
Abstract	A green and efficient method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones through one-pot three-component reaction of ethyl acetoacetate, an aryl aldehyde, and urea or thiourea in acetonitrile using silica gel-supported polyphosphoric acid (PPA-SiO₂) as catalyst is described. Compared to the classical Biginelli reaction conditions, the present methodology offers several advantages such as high yields, relatively short reaction times, mild reaction condition and a recyclable catalyst with a very easy work up.
Page	656 - 658
Full Text	PDF

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