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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 2
BKCSDE 32(2)
February 20, 2011 

Indirect Determination of Cetirizine Hydrochloride by ICP-AES
Wang Li sheng, Wei Xiao ling*, Gong Qi, Jiang zhi liang, Li Dong mei, Liang Qing
Cetirizine hydrochloride, ICP-AES, Precipitation, Indirect determination
Cetirizine hydrochloride reacted with BiI4 in an acidic aqueous solution to form precipitate. After centrifugation, the atomic emission intensity of Bi3+ contained in the supernatant solution was measured at the characteristic wavelength of 206.170 nm. The difference between the spectral signal intensity of the blank solution and that of the supernatant, ΔI, was linearly related to the concentration of cetirizine hydrochloride. As a result, a new inductively coupled plasmaatomic emission spectrometric (ICP-AES) method was developed for the analysis of cetirizine hydrochloride. The linear range was from 27.7 to 184.8 mg·L‒1, with a correlation coefficient (r) of 0.9961 and a detection limit of 9.6 mg·L‒1. This method is simple and accurate, Without using toxic organic solvents, and is feasible for the quality control of cetirizine hydrochloride tablets and capsules.
595 - 598
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