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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 32, Number 1
BKCSDE 32(1)
January 20, 2011 

Differential Effects of Cysteine and Histidine-Capped ZnS:Mn nanocrystals on Escherichia coli and Human Cells
Hoon Young Kong, Song Yi Kim, Jonghoe Byun*, Cheong Soo Hwang*
ZnS:Mn nanocrystal, Amino acid capping, Cytotoxicity, E. coli, Human cells
Cysteine and histidine-capped water-dispersible ZnS:Mn nanocrystals (ZnS:Mn-Cys and ZnS:Mn-His) were synthesized and their effects on E. coli and human cells were investigated. Particle sizes of these nanocrystals were found from HR-TEM images to be 3.5 nm and 4.0 nm, respectively. Their solution photoluminescence spectra showed identical broad emission peaks at 580 nm. ZnS:Mn-His significantly suppressed the growth of E. coli at 100 μg/mL and 1 mg/mL concentrations, something not observed with ZnS:Mn-Cys. Consistent with this, greater inhibition of cell proliferation and viability were observed in HEK293 and IMR90 cells in ZnS:Mn-His at 100 μg/mL and 1 mg/mL concentrations.
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