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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 12
BKCSDE 31(12)
December 20, 2010 

Mitochondrial Affinity of Guanidine-rich Molecular Transporters Built on myo- and scyllo-Inositol Scaffolds: Stereochemistry Dependency
Subhash C Ghosh, Boram Kim, Jungkyun Im, Woo Sirl Lee, Chang Nim Im, Young Tae Chang, Wanil Kim, Kyong Tai Kim, Sung Kee Chung*
Blood-brain barrier, Cellular membrane, Drug delivery, Inositol scaffold, Mitochondrial affinity
We prepared several novel molecular transporters built on myo- and scyllo-inositol scaffolds with variations in the number of guanidine residues, linker chain lengths and patterns. Some of these transporters were found to localize in mitochondria, and the mitochondrial affinity seems to be substantially related to the scaffold stereochemistry.
3623 - 3631
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