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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 12
BKCSDE 31(12)
December 20, 2010 

Generation of antagonistic RNA aptamers specific to proinflammatory cytokine interleukin-32
Seho Kim, Jung Hee Kim, Sujin Yoon, Keun Sik Kim, Moon Young Yoon, Do Young Yoon, Dong Eun Kim*
Interleukin-32, Proinflammatory cytokine, RNA aptamer, TNFα
Interleukin 32 (IL-32) is a recently identified cytokine that induces major proinflammatory cytokines such as TNFα and IL-1β, which play an important role in chronic inflammatory diseases. To antagonize the biological function of IL-32 in cells, we generated RNA aptamers that could bind specifically to IL-32 protein. The highest affinity aptamer, AC3-3, successfully antagonized IL-32 by abolishing the induction of TNFα in the human lung carcinoma cells expressing IL-32. This aptamer could be used as a potent and selective antagonist against IL-32 to further elucidate the roles of IL-32 in chronic inflammatory diseases, as well as a therapeutic agent.
3561 - 3566
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