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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 11
BKCSDE 31(11)
November 20, 2010 

Anti-Cancer Activity of T-Type Calcium Channel Blocker In Vivo
Hang Ah Park, Soo Yeon Jung, So Hyung Lee, Han Byul Kang, Min Sik Min, Jungahn Kim, Dong Joon Choo, Chun Rim Oh, Young Deuk Kim, Kyung Tae Lee, Jae Yeol Lee*
3,4-Dihydroquinazoline, Acute toxicity, A549 Xenograft, Anti-cancer
3,4-Dihydroquinazoline 1 as T-type calcium channel blocker was in vivo evaluated against A549 xenograft in BALB/c-nu Slc mice, which exhibited 54% tumor growth inhibition through oral administration of 8 mg/kg of body weight and was slightly less active than doxorubicin (68%). In addition, this compound was also profiled for its acute toxicity to ICR mice to afford oral LD50 value of 1,038 mg/kg of body weight.
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