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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 11
BKCSDE 31(11)
November 20, 2010 

Efficient Synthesis and in vitro PDT Effect of Purpurin-18-N-Aminoimides
Bing Cun Cui, Min Uk Cha, Jia Zhu Li, Ho Sung Park, Il Yoon, Young Key Shim*
Purpurin-18 methyl ester, Purpurin-18-N-aminoimide, Photodynamic therapy
A simple and efficient synthetic route for making purpurin-18-N-aminoimides is described. The purpurin-18-N-aminoimides are obtained by treatment of purpurin-18 methyl ester with various amines. These new compounds have long wavelength absorptions in the range of 706 - 711 nm. In preliminary screening, the purpurin-18-N-aminoimides have shown promising photosensitizing activity for the cancer cell by in vitro study in photodynamic therapy.
3313 - 3317
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