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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 11
BKCSDE 31(11)
November 20, 2010 

1,3-Dichloro-5,5-dimethylhydantoin as a Novel and Efficient Homogeneous Catalyst in Biginelli Reaction
Seyedeh Fatemeh Hojati*, Mostafa Gholizadeh, Mahnaz Haghdoust, Fatemeh Shafiezadeh
3,4-Dihydropyrimidin-2(1H)-one, 1,3-Dichloro-5,5-dimethylhydantoin, Homogeneous, Aldehyde,β-Dicarbonyl
A new and efficient method for the preparation of substituted 3,4-dihydropyrimidin-2(1H)-ones via Biginelli synthesis using catalytic amounts of 1,3-dichloro-5,5-dimethylhydantoin is presented. Short reaction times, easy work-up, high yields of products and stability, easy-handling, non-toxicity and cheapness of the catalyst are noteworthy advantages of the present work.
3238 - 3240
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