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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 9
BKCSDE 31(9)
September 20, 2010 
 
Title
 Design and Synthesis of Metallopeptide Sensors: Tuning Selectivity with Ligand Variation
Author
 Joung Min Kim, Bishnu Prasad Joshi, Keun Hyeung Lee*
Keywords
 Peptides, Zn2+, Cd2+, Peptide sensor, Chemical sensor
Abstract
 We chose a fluorescent pentapeptide sensor (-CPGHE) containing a dansyl fluorophore as a model peptide and investigated whether the selectivity and sensitivity of the peptides for heavy and transition metal ions could be tuned by changing amino acid sequence. In this process, we developed a selective peptide sensor, Cp1-d (-HHPGE, Kd = 670 nM) for detection of Zn2+ in 100% aqueous solution and a selective and sensitive peptide sensor, Cp1-e (-CCHPGE, Kd = 24 nM) for detection of Cd2+ in 100% aqueous solution. Overall results indicate that the selectivity and sensitivity of the metallopeptide sensors to specific heavy and transition metal ions can be tuned by changing amino acid sequence.
Page
 2537 - 2541
Full Text
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