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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 7
BKCSDE 31(7)
July 20, 2010 

Microwave Assisted One-pot Synthesis of Novel α-Aminophosphonates and Their Biological Activity
Alahari Janardhan Rao, Pasupuleti Visweswara Rao, Valsani Koteswara Rao, Challamchalla Mohan, Chamarthi Naga Raju*, Cirandur Suresh Reddy
Aminophosphonates, Microwave irradiation, Gram positive bacteria, Gram negative bacteria, Anti-oxidant activity
A simple and efficient synthesis of various α-aminophosphonates (3a-l) by the reaction of substituted aromatic/heterocyclic aldehydes, 2-amino-6-methoxy-benzothiazole and dibutyl/diphenyl phosphites under microwave irradiation without catalyst was accomplished. The phosphonates were characterized by elemental analysis, IR, 1H, 13C- and 31PNMR spectra. They showed promising antimicrobial, anti-oxidant activities depending on the nature of bioactive groups at the α-carbon.
1863 - 1868
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