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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 7
BKCSDE 31(7)
July 20, 2010 

Azide/Alkyne Resins for Quick Preparation of 1,4-Disubstituted 1,2,3-Triazoles
Uthaiwan Sirion, Jae Hak Lee, Yu Jin Bae, Hee Jun Kim, Byoung Se Lee*, Dae Yoon Chi*
Click chemistry, Azide/alkyne resins, 1,2,3-Triazole, Huisgen 1,3-dipolar cycloaddition reaction
An efficient method for the preparation of 1,4-disubstituted 1,2,3-triazole compounds is described using polymeric quaternary ammonium salts having azide or alkyne functionality to remove unreacted excess starting molecules (azide/alkyne). Copper metal could easily be removed by simple filtration with a short Na2SO4/silica cartridge, affording highly regioselective products in high yield and excellent purity without the need for work-up, extraction and chromatographic purification.
1843 - 1847
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