Current time in Korea 08:50 Apr 26 (Fri) Year 2024 KCS KCS Publications
KCS Publications
My Journal  Log In  Register
HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 7
BKCSDE 31(7)
July 20, 2010 

 
Title
Azide/Alkyne Resins for Quick Preparation of 1,4-Disubstituted 1,2,3-Triazoles
Author
Uthaiwan Sirion, Jae Hak Lee, Yu Jin Bae, Hee Jun Kim, Byoung Se Lee*, Dae Yoon Chi*
Keywords
Click chemistry, Azide/alkyne resins, 1,2,3-Triazole, Huisgen 1,3-dipolar cycloaddition reaction
Abstract
An efficient method for the preparation of 1,4-disubstituted 1,2,3-triazole compounds is described using polymeric quaternary ammonium salts having azide or alkyne functionality to remove unreacted excess starting molecules (azide/alkyne). Copper metal could easily be removed by simple filtration with a short Na2SO4/silica cartridge, affording highly regioselective products in high yield and excellent purity without the need for work-up, extraction and chromatographic purification.
Page
1843 - 1847
Full Text
PDF