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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 4
BKCSDE 31(4)
April 20, 2010 

A Convenient One-Pot Biginelli Reaction Catalyzed by Y(OAc)3:
An Improved Protocol for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones
and Their Sulfur Analogues
Gopalakrishnan Aridoss, Yeon Tae Jeong*
Biginelli reaction, 3,4-Dihydropyrimidin-2(1H)-one, Yttrium acetate
Yttrium(III) acetate hydrate-catalyzed novel synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one derivatives was achieved through one-pot three-component condensation of diversified aldehydes, 棺-ketoesters and urea or N-methylurea or thiourea with a molar ratio of 1:1:1.4. In comparison to the classical Biginelli approach, this catalytic method has the advantages of short reaction time and improved product yield.
863 - 868
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