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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 1
BKCSDE 31(1)
January 20, 2010

Title	Quinolone Alkaloids from Evodiae fructus Inhibit LFA-1/ICAM-1-mediated Cell Adhesion
Author	Seung Woong Lee, Jong Sun Chang, Ju Hwan Lim, Min Seok Kim, Su Jin Park, Hyung Jae Jeong, Min Soo Kim, Woo Song Lee, Mun Chual Rho
Keywords	Evodiae fructus, Rutaceae, Quinolone alkaloid, Cell adhesion molecules, THP-1 cells
Abstract	Four quinolone alkaloids were isolated by bioactivity-guided fractionation from the methanol extracts of Evodiae fructus fruits. Structures of compounds were elucidated by spectroscopic analysis (¹H-, ¹³C-NMR and MS), as follows: 1-methyl-2-undecyl-4(1H)-quinolone (1), evocarpine (2), dihydroevocarpine (3) and mixture of [1-methyl-2-[(Z)-10- pentadecenyl]-4(1H)-quinolone and 1-methyl-2-[(Z)-6-pentadecenyl]-4(1H)-quinolone] (4). They inhibited the interaction of sICAM-1 and LFA-1 in THP-1 cells at IC₅₀ values of >150 (1), 109.8 (2), >150 (3) and 40.9 μM (4), respectively,
Page	64 - 68
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