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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 11
BKCSDE 30(11)
November 20, 2009 

Synthesis and Biological Evaluation of 4-Heteroaryl-2-amino-5-methylimidazole Analogs as NHE-1 Inhibitors
Sunkyung Lee*, Kyu Yang Yi, Byung Ho Lee, Boo Soon Yoon
Sodium hydrogen exchanger type 1 (NHE-1) inhibitor, Non-acylguanidine, 4-Heteroaryl-2-amino-5-methylimidazole, Ischemia/reperfusion injury, Ischemic disease
To identify a non-acylguanidine NHE-1 inhibitor, an acylguanidne group was replaced with an imidazole group in the potent NHE-1 inhibitors with furan or benzothiphene core template, found from our previous studies. We synthesized and biologically evaluated 4-heteroaryl-2-amino-5-methylimidazole derivatives. All those imidazole compounds (16-18) represented the potent NHE-1 inhibitory activities, similar to the corresponding acylguanidine compounds.
2621 - 2625
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