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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 9
BKCSDE 30(9)
September 20, 2009

Title	Thermal Process for Enhancing Mechanical Strength of PLGA Nanoparticle Layers on Coronary Stents
Author	Jae ryang Joo, Hye Yeong Nam, So Hee Nam, Insu Baek, Jong Sang Park*
Keywords	Stent, Paclitaxel, PLGA, Nanoparticle, Thermal process
Abstract	Poly (lactic-co-glycolic acid) (PLGA) nanoparticles loading paclitaxel have been deposited on coronary stents by self-assembling properties of colloidal particles. The layers of the nanoparticles were enhanced to a sufficient mechanical strength by a thermal process under the proper temperature and humidity conditions. In vitro release studies proved the controlled paclitaxel release of the nanoparticle layers. This technique gives rise to a new range of applications for nanoparticles and drug-eluting stents.
Page	1985 - 1988
Full Text	PDF

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