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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 8
BKCSDE 30(8)
August 20, 2009 

New Phenylpropanoids from Sasa quelpaertensis Nakai with Tyrosinase Inhibition Activities
Nasim Sultana, Nam Ho Lee*
Sasa quelpaertensis, Isolation, Phenylpropanoids, Tyrosinase inhibition
Bioactivity-guided fractionation led to the isolation of two new phenylpropanoids, 3-O-p-coumaroyl-1-(4-hydroxy- 3,5-dimethoxyphenyl)-1-propanone (1) and 3-O-p-coumaroyl-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-O-β-gulcopyranosylpropanol (2), together with three known compounds, N-p-coumaroylserotonin (3), N-feruloylserotonin (4) and p-coumaric acid (5) from the leaves of Sasa quelpaertensis Nakai. Their structures were elucidated by spectroscopic methods including 1D and 2D-NMR. Compared to arbutin (IC50 0.048 mM) as a control, compounds 3 and 4 exhibited stronger tyrosinase inhibition activities with an IC50 values of 0.027 mM and 0.026 mM, respectively. Compounds 1 (IC50 0.055 mM) and 2 (IC50 0.053 mM) also showed strong activities.
1729 - 1732
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