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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 5
BKCSDE 30(5)
May 20, 2009

Title	Gamnamoside, a Phenylpropanoid Glycoside from Persimmon Leaves (Diospyros kaki) with an Inhibitory Effect against an Alcohol Metabolizing Enzyme
Author	Titto Varughese, Mozahidur Rahaman, No Soo Kim, Soon Chang Cho, Surk Sik Moon*
Keywords	Persimmon, Diospyros kaki, Gamnamoside, (-) Catechin, Alcohol dehydrogenase
Abstract	Phytochemical investigation of the methanolic extract of Diospyros kaki leaves led to the isolation of osmanthuside H (1) and a new phenol glycoside, named gamnamoside [4-(3-hydroxypropyl)-2-methoxyphenol β-D-apiofuranosyl( 1 → 6)β-D-glucopyranoside] (2) along with (-) catechin (3) through a series of reversed phase column chromatography and preparative C₁₈ HPLC. The structures of the isolates were determined by spectroscopic methods including IR, UV, HRTOFMS, and 2D NMR. Compounds 1, 2, and 3, showed good inhibitory activities (IC₅₀) of 175.4, 94.4, and 126.6 μg/mL respectively, whereas a reversible ADH inhibitor, 4-methylpyrazole, showed the IC₅₀ of 326.6 μg/mL against alcohol dehydrogenase (ADH).
Page	1035 - 1038
Full Text	PDF

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