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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 1
BKCSDE 30(1)
January 20, 2009 

α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus
Mohamed Elbandy, Pramod B Shinde, Jongki Hong, Kyung Sook Bae, Mi Ae Kim, Sang Mong Lee, Jee H Jung*
Sponge-derived fungus, Paecilomyces lilacinus, Pyrones, Cyclohexenones
New α-pyrones (1 and 2) and cyclohexenones (13 and 14) were isolated along with known analogues (3, 5?12) from the ethyl acetate extract of the whole broth of the fungus Paecilomyces lilacinus, a strain derived from a marine sponge Petrosia sp. Their structures were established by interpretation of 1D and 2D NMR, and FABMS data. It is interesting to isolate cyclohexenone derivatives from the genus Paecilomyces (family Trichocomaceae, order Eurotiales), since these cyclohexenones were previously reported only from far distinct genera, Phoma and Alternaria (family Pleosporaceae, order Pleosporales). Compounds 6, 7, and 9 were evaluated for cytotoxicity against a small panel of human solid tumor cell lines. Their cytotoxicity was insignificant upto a concentration of 30 μg/mL.
188 - 192
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