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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 1
BKCSDE 30(1)
January 20, 2009

Title	Stereoselective Synthesis of Diverse α-Hydroxy-β-amino Acids and It’s Application for Synthesis of Dipeptide Expecting as a Protease Inhibitor
Author	Sang Hun Jang, Ju Young Kim, Min Kyu Kim, Jeong Woo Han, Ki Hun Park, Yong Jin Yoon, Sang Gyeong Lee
Keywords	α-Hydroxy-β-amino acids, Nucleophilic addition, Epoxide ring opening, Eliminative cleavage
Abstract	General, fast, and efficient methods for the synthesis of Frechet-type dendrimers having core diversities were elaborated. Two core building blocks, 4,4'-(3,5-bis(propargyloxy)benzyloxy)bisphenyl and N,N,N',N'-tetra(prop-2- ynyloxycarbonylethyl)-1,2-diaminoethane, were designed to serve as the alkyne functionalities for dendrimer growth via click reactions with the azide-dendrons. The synthetic strategy involved an 1,3-dipolar cycloaddition reaction between an alkyne and an azide- functionalized Frechet-type dendrons in the presence of Cu(I) species which is known as the best example of click chemistry.
Page	163 - 171
Full Text	PDF

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