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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 11
BKCSDE 29(11)
November 20, 2008

Title	Synthesis and Antiproliferative Activities of Pyrrolo[2,3-d]pyrimidine Derivatives for Melanoma Cell
Author	Myung Ho Jung, Chang Hyun Oh*
Keywords	Pyrrolo[2,3-d]pyrimidine, A375, Antiproliferative activity
Abstract	The synthesis of a new series of diaryl ureas having a pyrrolo[2,3-d]pyrimidine scaffold is reported here. The in vitro antiproliferative activities of these diaryl derivatives against human melanoma cell line A375 were tested and the effect of substituents on the phenyl ring was investigated. The para substituted compounds Ia-g showed superior or similiar activity to Sorafenib against the A375 cell line. Among these compounds, Ic-e showed excellent activity against A375 compared with Sorafenib, a multi-kinase inhibitor.
Page	2231 - 0
Full Text	PDF

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