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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 11
BKCSDE 29(11)
November 20, 2008

Title	SAR Study of β-Aminoacyl-Containing Cyclic Hydrazide Derivatives as DPP-IV Inhibitors
Author	Mi Ae Jun, Mi Sik Shin, Woul Seong Park, Seung Kyu Kang, Ki Young Kim, Sang Dal Rhee, Duck Hyung Lee, Hyae Gyeong Cheon, Jin Hee Ahn, Sung Soo Kim
Keywords	Dipeptidyl peptidase IV, Diabetes, Cyclic hydrazide
Abstract	In continuation of our efforts to further derivatize dipeptidyl peptidase IV (DPP-IV) inhibitors, a series of β- aminoacyl-containing 5-, 6- and 7- membered cyclic hydrazide derivatives was synthesized. All the compounds were evaluated for their ability to inhibit DPP-IV, and an optimum structural unit on basic skeleton is identified to show good in vitro activity.
Page	2129 - 0
Full Text	PDF

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