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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 9
BKCSDE 29(9)
September 20, 2008 

Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using HClO4-SiO2
as a Heterogeneous and Recyclable Catalyst
Muchchintala Maheswara, Sang Hyun Oh, Ketack Kim, Jung Yun Do*
Dihydropyrimidinones, Dihydropyrimidinthiones, HClO4-SiO2, Silica-supported catalyst
A simple and efficient synthesis of 3,4-dihydropyrimidinones or thiones is described, using silica-supported perchloric acid (HClO4-SiO2) as a heterogeneous catalyst from an aldehyde, β-dicarbonyl compound, and urea or thiourea under solvent-free conditions. Compared to the classical Biginelli reactions, this method consistently has the advantage of high yields, short reaction time, easy separation, and tolerance towards various functional groups.
1752 - 1754
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