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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 8
BKCSDE 29(8)
August 20, 2008

Title	Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II
Author	Hyeong Beom Park, Myung Ho Jung, Jung-Hyuck Cho, Chang-Hyun Oh*
Keywords	1β -Methylcarbapenems, Antibacterial activity, Spiro[2,4]heptane, Substituent effects
Abstract	The synthesis of a new series of 1β-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the compounds were found to be more active compared to imipenem against Gram-negative bacteria. A particular compound (IIIc) having 7-oxo-5-azaspiro[2,4]heptane moiety showed the most potent antibacterial activity.
Page	1472 - 1478
Full Text	PDF

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