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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 8
BKCSDE 29(8)
August 20, 2008 

Discovery and Synthesis of Novel N-Cyanopyrazolidine and N-Cyanohexahydropyridazine Derivatives as Cathepsin Inhibitors
Jong Hwan Song, Sun Gi Kim, Zae Sung No, Young-Lan Hyun, Dong Ju Jeon*, Ikyon Kim*
Cathepsins, Rheumatoid arthritis, N-Cyanopyrazolidine, N-Cyanohexahydropyridazine
The design, synthesis, and biological evaluation of structurally novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors are described. In vitro assay reveals that several compounds exhibit highly potent and selective profiles against cathepsins K or S.
1467 - 1471
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