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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 6
BKCSDE 29(6)
June 20, 2008 

Gd-Complexes of DTPA-bis(amides) Functionalized by Pyridine and Picolinamide: Synthesis, Thermodynamic Stability, and Relaxivity Properties
Nasiruzzaman Sk, Md., Ji-Ae Park, Yongmin Chang,†*, Tae-Jeong Kim*
MRI CA, Gd(DTPA-bisamide), Pyridine, Picolinamide, T1 relaxivity
A series of DTPA-bis(amides) functionalized by pyridine (1a-c) and N-phenylpicolinamide) (1d-e) and their Gd(III)-complexes of the type [Gd(1)(H2O)]·xH2O (2a-e) were prepared and characterized by analytical and spectroscopic techniques. Potentiality of 2a-e as contrast agents for magnetic resonance imaging (MRI CA) was investigated by measuring relevant physicochemical properties and relaxivities and compared with [Gd(DTPA-BMA)(H2O)] (DTPA-BMA=N,N''-di(methylcarbamoylmethyl)diethylenetriamine-N,N',N''-triacetate) (OmniscanR). The R1 relaxivities of aqueous solutions of 2a-c are in the range of 3.33 -5.02 mM?1sec?1, which are comparable with those of OmniscanR (r1=4.58 mM?1sec?1). Complexes 2d-e, insoluble in water, exhibit relatively higher R1 values (8.1- 8.3 mM?1sec?1) in HP-β-CD solutions.
1211 - 1216
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