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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 2
BKCSDE 29(2)
February 20, 2008 

Discovery of Novel Transcription Factor Inhibitors Using a Pyrazole-based Small Molecule Library
Hyung-Ho Ha, B. Moon Kim*
Transcription factor, 5-Amino-3-pyrazole carboxamide, HIF-1α, NF-AT, Inhibitor
A focused library of pyrazole-based compounds was constructed towards novel transcription factor inhibitors. Complementary hydrogen bonding interaction with β-sheet peptide structures was the basis for the design of 5-amino-3-pyrazole carboxamide scaffold. From the preliminary inhibition assay against several transcription factors, compounds 7e and 8g were identified as novel lead compounds against HIF-1α and NF-AT transcription factors, respectively.
323 - 327
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