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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 12
BKCSDE 28(12)
December 20, 2007

Title	Design, Synthesis and Biological Activity of Certain 3,4-Disubstituted-5-mercapto-1,2,4-triazoles and Their Hydrazino Derivatives
Author	R. H. Udupi*, Sudheendra, Bheemachari, N. Srinivasulu, Rajesh Varnekar, Puranik Purushottamachar
Keywords	Triazoles, Anti-fungal, Anti-bacterial, Anti-inflammatory, Analgesic activity
Abstract	3-Aryloxy methyl-4-(N-pyrazin-2’yl carboxamido)-5-mercapto-1,2,4-triazoles (3a₁-a₁₄) were prepared starting from potassium dithio carbazinates (2a₁-a₁₄). These triazoles were then employed in the synthesis of 3-aryloxy methyl-4-(N-pyrazin-2’yl carboxamido)-5-hydrazino-1,2,4-triazoles (4a₁-a₁₄). All the newly synthesized compounds were characterized by analytical, IR, NMR spectral studies. The compounds were screened for their antibacterial, antifungal, anti-inflammatory and analgesic properties. Most of the compounds have shown significant antifungal activity while few have shown excellent anti-inflammatory and analgesic activity. An attempt is made to study the structure activity relationship (SAR).
Page	2235 - 0
Full Text	PDF

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