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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 11
BKCSDE 28(11)
November 20, 2007 

Boronated Porphyrins and Chlorins as Potential Anticancer Drugs
Valentina A. Ol'shevskaya, Andrey V. Zaytsev, Arina N. Savchenko, Alexander A. Shtil, Chan Seong Cheong, Valery N. Kalinin*
Carboranes, Porphyrins, Drug resistance, Photodynamic therapy, Boron neutron capture therapy
Analyzed are recent advances in design of novel boronared conjugates of synthetic and natural porphyrins and chlorins. These compounds showed high efficacy as cytotoxic agents for tumor cells in culture and as phototoxins in photodynamic therapy of tumor xenografts. Thus, boronated porphyrins and chlorins emerge as promising class of anticancer agents with potentially multiple advantages: the chemotherapeutic drugs alone and photo- and radiosensitizers in binary treatments.
1910 - 1916
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