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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 6
BKCSDE 28(6)
June 20, 2007

Title	Cytotoxic Polyketides from the Marine Sponge Discodermia calyx
Author	Pramod B. Shinde, Tayyab A. Mansoor, Xuan Luo, Jongki Hong, Chong-O. Lee, Jee H. Jung*
Keywords	Marine sponge, Discodermia calyx, Polyketide, Cytotoxicity, Marfey analysis
Abstract	Bioassay-guided fractionation of the MeOH extract from the sponge Discodermia calyx collected off the coast of Jeju Island, South Korea, led to the isolation of a polyketide, icadamide C (1), along with previously reported theopederin K (3). Structure elucidation was performed by a combination of high resolution mass and 2D-NMR (principally COSY, HMBC, HSQC, and NOESY) spectroscopy. Stereochemistry of compound 1 was determined as 2R, 3R, 6R, 10S, 11S, 12R, 13S, 15R and 2'S by NMR data and Marfey analysis. Isolated metabolites displayed potent cytotoxic activity against a small panel of five human solid tumor cell lines with ED₅₀ values of less than 0.1 μg/mL.
Page	990 - 0
Full Text	PDF

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