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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 2
BKCSDE 28(2)
February 20, 2007 

New Cholinesterase Inhibitor, Lipoic Acid-Nitrone Derivatives
Yun Mi Seo, Kang Hee Nam, Pill Seong Kang, Sung Bo Ko, Eugene Oh, Min Tae Sung, Byoung Wook Choi, Bong Ho Lee*, Jeong Ho Park*
Lipoic acid, Nitrone, Antioxidant, Cholinesterase inhibitor
Lipoic acid (LA) is a multifunctional antioxidant against a variety of ROS. Nitrone acts as free radical spin trap and exhibits neuroprotective activity. Thus, LA-nitrone derivatives (6, 7, 8, and 9) were synthesized and screened as an antioxidant and inhibitors for cholinesterases. Even though the antioxidant effect of LA-nitrone derivatives was not improved, they turned out to be effective inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in μM range.
225 - 228
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