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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 2
BKCSDE 28(2)
February 20, 2007

Title	New Cholinesterase Inhibitor, Lipoic Acid-Nitrone Derivatives
Author	Yun Mi Seo, Kang Hee Nam, Pill Seong Kang, Sung Bo Ko, Eugene Oh, Min Tae Sung, Byoung Wook Choi, Bong Ho Lee, Jeong Ho Park
Keywords	Lipoic acid, Nitrone, Antioxidant, Cholinesterase inhibitor
Abstract	Lipoic acid (LA) is a multifunctional antioxidant against a variety of ROS. Nitrone acts as free radical spin trap and exhibits neuroprotective activity. Thus, LA-nitrone derivatives (6, 7, 8, and 9) were synthesized and screened as an antioxidant and inhibitors for cholinesterases. Even though the antioxidant effect of LA-nitrone derivatives was not improved, they turned out to be effective inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in μM range.
Page	225 - 228
Full Text	PDF

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