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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 1
BKCSDE 28(1)
January 20, 2007 

Ester Derivatives from Tannase-treated Prunioside A and Their Anti-inflammatory Activities
Chang-Soo Jun, Myung-Ja Yoo, Woo-Yiel Lee, Kyung-Chell Kwak, Moon-Sung Bae, Woo-Taek Hwang, Dong-Hwan Son, Kyu-Yun Chai*
Spiraea prunifolia, Prunioside A, Nitric oxide, NO production, Inhibitory effects
Prunioside A, isolated from the methanol extract of Spiraea prunifolia var. Simpliciflora’s root, is composed of coumaroyl, monoterpene-type, and glucosyl units. The esterase activity of tannase was used to remove the p-coumaroyl and glucopyranosyl groups. The enzymatically hydrolyzed compound was reacted with various acyl chlorides to synthesize its ester derivatives, which showed the inhibitory effects on NO production in murine machrophage?like RAW 264.7 cells stimulated with lipopolysaccharide and interferon-γ.
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