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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 10
BKCSDE 27(10)
October 20, 2006

Title	Some of the Food Color Additives Are Potent Inhibitors of Human Protein Tyrosine Phosphatases
Author	Suja Shrestha, Bharat Raj Bhattarai, Keun-Hyeung Lee, Hyeongjin Cho
Keywords	Food color additive, Certified color, Dye, Protein tyrosine phosphatase, Enzyme inhibitor
Abstract	Synthetic color additives approved for general food use are sixteen in European Union, seven in U. S. A. and twelve in Japan. Twelve food dyes were examined for their inhibitory potency against human protein tyrosine phosphatases (PTPases). Half of the food colorants inhibited PTPases significantly and three of them were potent inhibitors with low micromolar IC₅₀ values. Also examined were the synthetic dyes structurally similar but not allowed in food. Some of them were potent inhibitors of PTPases. Considering the importance of PTPases in cellular signal transduction, inhibition of PTPases by food colorants might cause harmful effects in human health.
Page	1567 - 1571
Full Text	PDF

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