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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 9
BKCSDE 27(9)
September 20, 2006 

Complexation between Venlafaxine Hydrochloride and β -Cyclodextrin:Structural Study by Nuclear Magnetic Resonance Spectroscopy
Syed Mashhood Ali*, Fahmeena Asmat, Mamoru Koketsu
β-Cyclodextrin, Venlafaxine hydrochloride, Inclusion complexes, 1H NMR titration, ROESY
A detailed spectroscopic study (1H NMR, COSY, ROESY) of complexation of venlafaxine hydrochloride (VEN) with β-cyclodextrin (β-CD) was carried out in solution. The stoichiometry of the complex was determined to be 1 : 1 and penetration of aromatic ring into β-Cyclodextrin cavity was confirmed from primary rim side, with the help of ROESY spectral data. The structure of the venlafaxine hydrochloride-β-CD complex has been proposed. The association constant was determined to be 234 M-1.
1397 - 1400
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