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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 9
BKCSDE 27(9)
September 20, 2006 

Synthesis and Biological Evaluation of 3-Amino-4-aryl-piperidine Derivatives as BACE 1 Inhibitors
Hee-Jong Lim*, Myung Hee Jung, Ihl Young Choi Lee, Woo Kyu Park
Alzheimer’s disease (AD), BACE 1 (β-secretase), Non-peptidomimetic inhibitors, Piperidine derivatives
BACE 1 (β-secretase), a membrane bound aspartic protease, is a key enzyme in the process of amyloid precursor protein (APP) into Aβ peptide which is considered to play a causative role in Alzheimer’s Disease (AD). Here, we reported the synthesis and inhibitory activity of optically active 3-amino-4-aryl-piperidines.
1371 - 1376
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