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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 8
BKCSDE 27(8)
August 20, 2006 
 
Title
 99mTc(CO)3-Labeled Histidine-Arylpiperazines as Potential Radiotracers for a Neuroreceptor Targeting
Author
 Kang-hyuk Choi, Young-Don Hong, Ok-Ja Choi, Sun-Ju Choi*
Keywords
 Neuroreceptor, Arylpiperazine, 5-HT1A, Histidine derivative, 99mTc(CO)3
Abstract
 In order to develop radiopharmaceuticals for targeting a serotonin receptor such as 5-HT1A, histidine-Cnarylpiperazines (AP) (C = alkyl, n = 2, 3, 4) were prepared in five steps with yields of 25%, 37% and 51%, respectively, and radiolabeled with the [99mTc(CO)3(H2O)3]+. The 99mTc(CO)3-Histidine-Cn-APs were prepared with a high yield (>99%) and characterized as a tridentate complex with a neutral charge to pass through the blood-brain barrier (BBB). The rhenium complexes with Re(CO)3 were also synthesised and comparative experiments were achieved to evaluate the nature of the 99mTc complexes.
Page
 1189 - 1193
Full Text
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