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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 8
BKCSDE 27(8)
August 20, 2006

Title	Synthesis and Antibacterial Activity of 1β-Methyl-2-[5-(α,β-disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem Derivatives. Part II
Author	Jin-Woong Kim, Hyeong Beom Park, Bong Young Chung, Jong Baek Lee, Jung-Hyuck Cho, Chang-Hyun Oh*
Keywords	1β-Methylcarbapenem, Antibacterial activity, DHP-I stability
Abstract	The synthesis of a new series of 1β-methylcarbapenems having 5-(α,β-disubstituted ethyl)pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound (VIh) having α-hydroxy-β-piperazinylethyl substituted moiety showed the most potent activity.
Page	1164 - 1170
Full Text	PDF

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