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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 26, Number 11
BKCSDE 26(11)
November 20, 2005 

 
Title
Simple Synthesis of Novel 1',4'-Dimethyl Branched Carbovir Analogues
Author
Aihong Kim, Joon Hee Hong*
Keywords
Antiviral agents, Branched nucleoside, Carbocyclic nucleoside
Abstract
Novel 1',4'-dimethyl branched carbocyclic nucleosides were synthesized from acetol. The 4'-methyl group was installed via a Claisen rearrangement reaction, and the carbonyl addition of methylmagnesium bromide was used to introduce the 1'-methyl group. The coupling of nucleosidic bases and desilylation was used to produce a series of novel nucleosides.
Page
1767 - 1770
Full Text
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