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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 26, Number 11
BKCSDE 26(11)
November 20, 2005

Title	Rapid Synthesis of Arylpiperazine Derivatives for Imaging 5-HT_1A Receptor under Microwave Irradiation
Author	Sang Hyun Park*, Hui Jeong Gwon, Hyo Sun Lee, Kyung Bae Park
Keywords	Arylpiperazines, Serotonin receptors, Microwave irradiation
Abstract	We have established an efficient method for the synthesis of the arylpiperazine derivatives in which the acylation of 2-aminopyridine, the coupling reaction of the acyl compound with piperazines, and reduction of the arylpiperazines were performed under a microwave irradiation (300 W) to afford the corresponding target compounds in quantitative yields. In all cases, the reaction times were remarkably reduced when compared with those of the conventional method.
Page	1701 - 1705
Full Text	PDF

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