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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 12
BKCSDE 25(12)
December 20, 2004 

Correlation Equation for Retention Factor and Resolution of Ibuprofen in SFC
Soon Koo Han, Yinzhe Jin, Kyung Ho Row*
SFC, Retention factor, Resolution, Ibuprofen, Correlation
Supercritical fluid chromatography (SFC) was considered for separating racemic ibuprofen. The chromatographic column (3.9 × 150 mm) was packed with Kromasil? CHI-TBB, and the mobile phase was supercritical carbon dioxide with modifier of IPA. The experimental variables were the content of IPA, and temperature and pressure of supercritical mobile phase. To determine the separation condition, the empirical equation of retention factor and resolution was proposed. In the case of retention factor, the empirical equation was in the form, k = a ρ + b/F + c ( ρ/F) + d. The empirical equation for resolution was proposed as a linear form, R = a ρ + b F + c.
1807 - 1811
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