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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 12
BKCSDE 25(12)
December 20, 2004 

Simultaneous Derivative Spectrophotometric Determination of Levodopa and Carbidopa in Pharmaceutical Preparations
T. Madrakian*, A. Afkhami, M. Borazjani, M. Bahram
Derivative spectrophotometry, Simultaneous determination, Levodopa, Carbidopa
The present work reports on the investigations based on the interaction of sodium hydroxide with catechol derivatives. The first derivative spectra allowed the simultaneous determination of levodopa and carbidopa. The calibration graph was constructed from the first derivative signals by measuring 1D at 350 nm for standard samples containing between 3 and 30 mg L?1 of levodopa and at 305 nm for standard samples containing between 3 and 80 mg L?1 of carbidopa. This method offers the advantages of simplicity, rapidity, selectivity and higher sensitivity than most of the existing spectophotometric methods.
1764 - 1768
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