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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 25, Number 9
BKCSDE 25(9)
September 20, 2004 

 
Title
Synthesis of Oxazolidinone Phosphonate Derivatives, Part I
Author
Jae-Min Hwang, Woon-Seob Shin, Kang-Yeoun Jung*
Keywords
Oxazolidinone, Oxazolidinone phosphonates, Antibacterial agent, N-Arylation, γ-Ketophosphonate
Abstract
Several new derivatives of oxazolidinone phosphonate, that are expected to show biological activity, were prepared efficiently by previously published methods. γ-Ketophosphonate 1 was synthesized using pentacovalent oxaphosphorane chemistry followed by reductive amination with aromatic amine of oxazolidinone 4. Biological activity of the synthetic compounds has been studied. One of the synthetic compounds showed promising result for us to pursue further studies.
Page
1326 - 1330
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